By C.-A. Andreae (auth.), Professor C. Prys-Roberts, Professor M. D. Vickers (eds.)

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1 m1 Fentanyl 50 Ilg: 1 m1 intramuscularly Group 3. 1 ml Normal saline: 1 m1 intramuscularly The nature of the injected solution was unknown to the anaesthetist who performed the block and did the evaluation. As well as clinical monitoring of circulation and ventilation, onset time, level, intensity and duration of analgesia were assessed. Analgesia was defined as the loss of sensation of cold (application of ether to the skin) and lack of reaction to surgical stimuli. The per and postoperative reactivity were graded as follows: Grade 1: patient sleepy; no reaction to surgical stimuli Grade 2: patient awake; no reaction to stimuli Grade 3: patient awake; minor and transient reaction not requiring supplementation with analgesics or seaatives Grade 4: patient awake; reaction requiring additional analgesia or anaesthesia The haemodynamic state was assessed at 5 min intervals during the first hour, and at 10 min intervals thereafter.

15 mY. These bursts are non-rhythmic as well, remain constant in each individual rabbit and may appear superimposed on, or between, the waves ofthe SPA. Seven to nine min following spinal injection of morphine, a gradual and marked increase of all the parameters of both the SPA and FPA became apparent in all ten rabbits. 36 Effect of Spinal Morphine on the Electrophysiological Activity Fig. 3. Electrophysiological activity of ureteric muscle, 10 min after spinal injection of morphine. Same calibration as in Fig.

Alter U et al (1974) Effizienzmessungen im Gesundheitswesen. Deutsches Arzteblatt, 3262,46,3338 28. J. Hull and S. Bower The pharmacokinetic characteristics of alfentanil were compared with those of fentanyl in seven healthy volunteers. 5 min Lv. infusion. Venous blood samples were taken over the period 0-360 min and the plasma separated and stored at -20°C until assay. Each sample was assayed in triplicate for fentanyl and alfentanil content, by independent radio-immunoassays. The molar ratio of cross-reactivity of each drug in assay for the other was less than 10-4 in both cases.

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Cardiovascular Measurement in Anaesthesiology by C.-A. Andreae (auth.), Professor C. Prys-Roberts, Professor
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