By Ulf Landmesser, Helmut Drexler (auth.), Martial G. Bourassa, Jean-Claude Tardif (eds.)
Antioxidants and heart problems, moment variation addresses a posh yet very well timed and interesting challenge in cardiovascular drugs. it really is written via famous specialists within the fields of atherosclerosis and antioxidants. it's going to be of curiosity not just to academicians but additionally to practising physicians. the 1st 5 chapters overview the overall ideas of oxidative tension and their dating to lipid metabolism, endothelial disorder, genetics and transcriptional components. the subsequent seven chapters describe lately outlined markers of oxidative rigidity, pharmacological compounds with antioxidant job, usual antioxidants present in micronutrients and in nutrient-rich diets, and studies the new proof for his or her efficacy or loss of efficacy in sufferers with heart problems or cardiovascular danger elements. The final seven chapters speak about the aptitude healing advantages of antioxidants in a few cardiovascular stipulations which come with atherosclerosis, restenosis after percutaneous coronary intervention, significant cardiovascular possibility elements reminiscent of high blood pressure, diabetes mellitus and dyslipidemia, and left ventricular disorder and congestive middle failure.
Martial G. Bourassa, M.D. and Jean-Claude Tardif, M.D. are affiliated with the Montreal center Institute, study heart and division of medication, college of medication, collage of Montreal, Montreal, Quebec, Canada.
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Inhibition of vasodilatation in response to nitric oxide Arteries exposed to OxLDL in vitro show an endothelium-dependent vasodilator impairment^^^^\ Clinical studies show that treatment of patients with coronary artery disease with statins and/or antioxidant compounds can improve endothelial-dependent coronary vasomotion^^^^'^^^\ Several studies have shown that circulating OxLDL levels have been associated with endothelial dysfunction^^^^\ For example, Tamai et al showed that a single session of LDL apheresis significantly increased brachial artery acetylcholine-induced flow mediated dilatation (FMD) within four hours.
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