By Roger J. Laham, Donald S. Baim

An interdisciplinary panel of pioneers and opinion leaders assessment the elemental, preclinical, medical, and developmental pathways to new therapy recommendations, corresponding to healing angiogenesis and myogenesis. The authors make the most of new organic knowing, novel healing objectives, a number of on hand and well-studied healing innovations, and the required imaging ideas to degree results. Their in-depth discussions hide the identity of recent healing ambitions and pathways, the research of transcriptional components, grasp change molecules, cell-based techniques, chemokines, a greater knowing of the results of getting older, endothelial disorder, and hypercholesterolemia in keeping with angiogenic stimuli. Highlights contain exam of drug supply difficulties, results degree, stem remedy, high-risk interventions, improvement pathways, and destiny probabilities.

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Tie2 gene expression has been shown to be regulated by the ETS factors NERF, ELF-1, and Fli-1 (4,7,48). One of the key regulators of AP-1 expression is the transcription factor AML1. Targeted disruption of this factor led to abnormalities in angiogenesis that could be rescued by administration of AP-1 (53). Another transcription factor that also appears to regulate AP1 levels is the nuclear receptor COUP-TFII (54). Targeted disruption of this gene is associated with angiogenic defects and marked reductions in the level of AP-1.

By combining the ameroid model with the Vineberg operation, a systemic artery can be brought into contact with the coronary circulation in a collateral-dependent area. This artery has the potential to develop collateral circulation in communication with the myocardium and can be implanted with an infusion pump to administer angiogenic agents and enhance the development of systemic-to-coronary anastomoses. This model is unique because it can be used in patients with severe multivessel disease and no patent feeder artery.

J Cell Biol 1997;139:257–264. 31. Liao W, Ho C, Yan YL, Postlethwait J, Stainier DY. Hhex and scl function in parallel to regulate early endothelial and blood differentiation in zebrafish. Development 2000;127:4303–4313. 32. Kennedy M, Firpo M, Choi K, et al. A common precursor for primitive erythropoiesis and definitive haematopoiesis. Nature 1997;386:488–493. 33. Choi K, Kennedy M, Kazarov A, Papadimitriou JC, Keller G. A common precursor for hematopoietic and endothelial cells. Development 1998;125:725–732.

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Angiogenesis and direct myocardial revascularization by Roger J. Laham, Donald S. Baim
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